The Workshop "Graphing Genes, Cells and Embryos"

hosted by
Stazione Zoologica, Naples, May 17-20, 2007

organized by
Center of Science Studies, Estonian University of Life Sciences, Tartu (Estonia)
INSERM ERM206 - TAGC, Marseille (France)
Max Planck Institute for the History of Science, Berlin (Germany)
Konrad Lorenz Institute for Evolution and Cognition Research, Altenberg (Austria)


An important feature of the life sciences is that they always have visualized their objects to a greater extent than physics or chemistry. Since the early 19th century one extensively used hand-drawings, professional illustrations, idealized diagrams, microphotography, and, in the 20th century, time-lapse motion pictures to visualize the data and to support one's own analyses. Nowadays the techniques expanded to video and digital imaging, including virtual reality dissections and rotating panoramas of embryonic features. In general, these scientific images are means to store and exchange experi-mental data and to further specialized knowledge of biological objects. The objects are either an individual, like an embryo or egg, a cell or gene, or sets of individuals like animals, plants, forests, or meadows. What distinguishes them from physical entities are the facts that they are visually flexible phenomena whose boundaries, extension and identifying details are studied to explain life's dynamics and such processes like embryogenesis, cell mor-phologies, or genes' networking.

To capture this visual specificity of the life sciences, the workshops will focus (1) on the biological material considered in priority, e.g. embryos, cells, and genes, (2) on the type of graphical representations used, e.g. fate maps, cell lineages, or gene networks, and (3) on the techniques employed to construct these graphs, e.g. hand drawings, diagrams, tables, micro-photographs, time-lapse motion pictures, or computer imaging.

This workshop brings to an issue the production of biological knowledge on embryos, cells, and genes from the early 19th to in silico biology. For it, we will compare the graphic models of classical  isciplines evoking lifelike images within the mind, like embryology and cytology to most recent computer imaging techniques. In terms of methodology we want to foster true interdisciplinary work and communication, in particular combining experts from the biological sciences and the humanities (history and philosophy of sciences). Our discussions will serve several objectives. For example, we will study biological objects and follow their traces in different disciplines over time, we will examine the tools by which biologists visualized their observations, and how they trained themselves to 'observe' and to 'imagine' the pheno-menal forms of biological bodies. Further we will elucidate in detail which experimental procedures schooled the scientists to coordinate eyes and hands when redrawing over and over again images of cells pushing against each other, or fixing the boundaries of embryonic layers, permanently moving and shifting their position inside an embryo.

 Other epistemic questions we want to address here are how the 'graphs' relate to the experiments in question, or how the images changed when more data accumulated. For, the workshops attempt to underline the role of images as a vehicle of how the scientists comprehend the object or phenomenon in question, and of how they differentiate or unify biological diversity in coherent theories. Indeed, scientific images do not map experimental reality in a one-to-one correspondence because they result from a complex process of production and  transformation. In other words, scientific images are models.

During the workshops biologists and scholars of science studies will elucidate to what extent the images have served and still serve the biologists to perceive and to cognize living entities. Thus, we will also talk in detail on the scientist's perceptive habit and the ambiguity of observing epistemic objects, which are at the same time subjects changing their shape in time and space. The interdisciplinary participants will offer a variety of foci when presenting the practicer of scientific visualization, discussing the function and modi of visual representation, or delimiting the role that images can play in accepting a new 'theory'. Further, we will explore the emergence of novel graphical representation strategies to cope with very large sets of experimental data produced by functional genomic approaches. Scientists involved in the growing field of systems biology particularly stress the need for efficient representation and modelling to enable the required interdisciplinary cooperation. In the process, several other aspects are alluded to, e.g. the credibility of the experimenter, or the visibility and communicability of science.

The biological scientists will present their own research on the mechanism that coordinate cell movements with gene expression, on gene regulatory networks, on the patterning of cell lineages, or on the evolution of morphological characters. They will exemplify which tools they use, e.g. hand drawings, diagrams, statistical tables, scanning electron microscopy, video laser, digital imaging, or the formal graphical representation. They will unravel how they analyze their data, conceptualize their mental images, and formulate 'theories'. Each 'biological' presentation will be backed up by a historical and/or philosophical one, either showing the continuity of research issues and biological theories, or pointing out the distinctions to studies of the life sciences of the 19th and 20th century.
Tentatively, the analyses presented in these workshops will contribute to the development of a grammar of visual representation in the life sciences. In any case, the universa in picto and their fabrication from a period of nearly 200 years will constitute the common theme.


Sabine Brauckmann . Christina Brandt . Denis Thieffry . Gerd B. Müller